Research Articles
Definitive Endoderm Specification: A Cross-Species Guide to Mouse and Pig Models for Disease Research
This article provides a comprehensive comparative analysis of definitive endoderm (DE) specification in mouse and pig models, addressing the critical needs of researchers and drug development professionals.
Cross-Species Gastrulation Transcriptome Conservation: From Evolutionary Insights to Biomedical Applications
This comprehensive review synthesizes current research on cross-species transcriptome conservation during gastrulation, a pivotal developmental period.
Controlling Batch Effects in Gastruloid Culture: A Comprehensive Guide to Medium Component Variability and Optimization
This article provides a comprehensive examination of batch effects stemming from medium components in gastruloid culture systems, addressing a critical challenge in stem cell research and developmental biology.
Mapping the Phosphoproteome: Decoding Signaling Networks in Gastrulation and Beyond
This article provides a comprehensive exploration of phosphoproteomics and its pivotal role in dissecting the complex signaling networks that orchestrate gastrulation.
Strategies for Enhancing Gastruloid Reproducibility and Robustness in Biomedical Research
Gastruloids, three-dimensional in vitro models derived from pluripotent stem cells, have emerged as powerful tools for studying early embryogenesis and developmental disorders.
Navigating Pluripotency: How Pre-Growth Conditions Dictate Stem Cell Fate and Function
This article provides a comprehensive analysis of how pre-growth conditions fundamentally shape the pluripotency state of stem cells, with direct consequences for their stability, differentiation potential, and utility in research...
Micropattern Differentiation in Gastrulation Models: A Guide for Researchers and Drug Developers
This article provides a comprehensive overview of micropatterned gastrulation models, a transformative bioengineering technology that enables the reproducible study of early human development in vitro.
PAR Proteins and Gastrulation: Orchestrating Cell Polarity and Movement in C. elegans Development
This article synthesizes current research on the fundamental role of PAR proteins in controlling gastrulation in C.
Vitamin A as a Key Regulator of Hox Genes and Limb Development in Anuran Models
This article explores the pivotal role of Vitamin A (retinoic acid) in manipulating Hox gene expression to direct profound developmental outcomes, specifically homeotic transformations in anuran models.
Optimizing Mouse Embryo Vitrification: Molecular Mechanisms, Fast Protocols, and Improved Survival Strategies
This article synthesizes current research on vitrified-warmed mouse embryo survival, addressing key challenges and methodological advances.