Research Articles
Decoding Hox-Mediated Skeletal Transformations: From Molecular Mechanisms to Therapeutic Insights
This article provides a comprehensive resource for researchers and drug development professionals grappling with the complexities of interpreting Hox gene function in skeletal patterning.
Optimizing Hox Gene Expression Detection in Early Limb Buds: From Foundational Principles to Advanced Single-Cell Resolution
This comprehensive review addresses the critical challenge of detecting Hox gene expression during early limb bud development, where precise spatiotemporal patterns establish anterior-posterior positioning.
Strategies for Conditional Deletion of Hox Gene Function in Limb Mesenchyme: From Foundational Principles to Advanced Applications
This article provides a comprehensive guide for researchers and drug development professionals on implementing conditional gene deletion to investigate Hox gene function in limb mesenchyme.
Decoding Subtle Limb Patterning: Advanced Methods for Analyzing Hox Mutant Phenotypes
This article provides a comprehensive guide for researchers and drug development professionals on the current methodologies for identifying and characterizing subtle limb patterning phenotypes in Hox gene mutants.
Beyond Development: Hox Genes as Master Regulators of Limb Stromal Connective Tissues in Patterning, Repair, and Disease
This article synthesizes current research on the critical, ongoing functions of Hox genes within limb stromal connective tissues, moving beyond their well-established embryonic roles.
Hox Gene Expression in Zebrafish Pectoral Fin Development: Mechanisms, Models, and Evolutionary Insights
This article provides a comprehensive analysis of Hox gene expression and its critical function in zebrafish pectoral fin development, a key model for understanding vertebrate paired appendage formation.
Dominant-Negative Hox Constructs: From Functional Perturbation to Therapeutic Potential
Dominant-negative Hox constructs represent a powerful methodological approach to dissect the functional redundancy and oncogenic roles of HOX transcription factors in development and disease.
Hox Compound Mutants in Mice: Unraveling Genetic Redundancy and Regulatory Networks in Limb Development
This article synthesizes current methodologies and findings from the generation and analysis of Hox compound mutant mice, providing a comprehensive resource for researchers investigating limb development.
CRISPR-Cas9 Mutagenesis of Hox Clusters: Decoding the Genetic Blueprint of Vertebrate Limb Development
This article synthesizes recent advances in CRISPR-Cas9 applications for functional analysis of Hox gene clusters in vertebrate limb development.
Hox Genes as Master Regulators of Limb Musculoskeletal Patterning and Regeneration
This article synthesizes current research on Hox genes, evolutionarily conserved transcription factors that establish positional identity along the limb axes during embryonic development.