Research Articles
Cellular Heterogeneity in Human Embryo Development: Single-Cell Insights into Fate, Function, and Clinical Translation
This article synthesizes the latest advances in understanding cellular heterogeneity during human embryogenesis, driven by single-cell omics technologies.
A Comprehensive Guide to Validating CRISPR Edits in Patient-Derived Organoid Models
This article provides a systematic framework for researchers and drug development professionals to validate CRISPR-Cas9 edits in patient-derived organoids (PDOs).
Mechanical Cues in Bone Organoid Development: From Biomechanical Sensing to Advanced Biofabrication
Bone organoids represent a transformative platform for studying bone development, disease modeling, and drug screening.
Overcoming the Vascularization Bottleneck: Strategies for Functional and Mature Organoid Models
This article provides a comprehensive overview of the critical challenge of insufficient vascularization in organoid models and the innovative strategies being developed to overcome it.
Mastering EB Formation: Advanced Techniques for Controlling Organoid Size and Differentiation
This article provides a comprehensive guide for researchers and drug development professionals on achieving high uniformity in embryoid body (EB) formation, a critical step for reproducible organoid generation.
Harnessing Pluripotency: How Stem Cell Plasticity Drives Advanced Organoid Development for Biomedical Research
This article explores the critical role of the pluripotent state in human stem cells for the successful differentiation of three-dimensional organoids.
BMP Signaling in Retinal Organoid Differentiation: Enhancing Efficiency, Reproducibility, and Clinical Translation
This article synthesizes current research on the critical role of Bone Morphogenetic Protein (BMP) signaling in optimizing retinal organoid differentiation from human pluripotent stem cells.
Optimizing Neural Organoid Culture: A Comprehensive Guide to Geltrex Matrix Encapsulation
This article provides a detailed guide for researchers and drug development professionals on using Geltrex matrix for neural organoid culture.
RNAscope vs. HCR v3.0: A Comprehensive Guide to Specificity, Background, and Performance
This article provides a detailed comparative analysis for researchers and drug development professionals on two powerful in situ hybridization technologies: RNAscope and Hybridization Chain Reaction v3.0 (HCR v3.0).
Mastering Background Control: Whole-Mount vs. Section In Situ Hybridization for Precision Research
This article provides a comprehensive guide for researchers and drug development professionals on managing background noise in whole-mount versus sectioned in situ hybridization (ISH).