Research Articles
Optimizing Germline Transmission in Zebrafish CRISPR Mutants: A Guide for Functional Genomics and Disease Modeling
This article provides a comprehensive overview of strategies for achieving efficient germline transmission of CRISPR-Cas9-induced mutations in zebrafish, a critical vertebrate model for functional genomics and drug discovery.
Gastruloid vs. In Vivo Embryo Transcriptome: A Comprehensive Guide for Developmental Biology and Drug Discovery
This article provides a comprehensive analysis of the transcriptional landscapes of gastruloids and in vivo embryos, serving as a critical resource for researchers and drug development professionals.
How Cell Fate Specification Modes Govern Transcriptome Evolution: From Embryogenesis to Biomedical Applications
This article synthesizes recent advances in understanding how distinct modes of cell fate specification—autonomous versus conditional—shape the evolution of transcriptomes during embryonic development.
Heterochrony in Extraembryonic Development: Evolutionary Mechanisms and Biomedical Applications
This article synthesizes contemporary research on heterochrony—evolutionary changes in developmental timing—focusing on its critical role in extraembryonic development across species.
ZEB2 in Somitogenesis: Unraveling its Critical Role in Mouse and Human Development
This article synthesizes current research on the transcription factor ZEB2 and its indispensable function in mouse and human somitogenesis.
Controlling Gastruloid Variability: Strategies for Reproducible Embryonic Development Models
Gastruloids, three-dimensional stem cell aggregates that model embryonic development, show immense promise for fundamental research and drug development.
Controlling Endoderm Morphogenesis Variability in Gastruloids: From Foundational Concepts to Optimized Protocols
This article provides a comprehensive analysis of the sources and control strategies for endoderm morphogenesis variability in gastruloids, three-dimensional embryonic organoids.
Navigating Gastruloid Cell Line Differentiation Propensity: From Foundational Principles to Optimized Applications
This article provides a comprehensive resource for researchers and drug development professionals on the critical factor of cell line differentiation propensity in gastruloid models.
Decoding Gastrulation: A Comprehensive Single-Cell RNA Sequencing Atlas for Developmental Biology and Disease Modeling
This article synthesizes the transformative impact of single-cell RNA sequencing (scRNA-seq) in constructing high-resolution atlases of gastrulation across multiple mammalian species.
Decoding Gastrulation: A Single-Cell RNA Sequencing Atlas Reshaping Developmental Biology and Drug Discovery
This article provides a comprehensive overview of how single-cell RNA sequencing (scRNA-seq) is revolutionizing our understanding of gastrulation, a fundamental but poorly understood stage in early human development.