Research Articles
HoxA vs. HoxD in Limb Patterning: Functional Divergence, Regulatory Synergy, and Clinical Implications
This review synthesizes current research on the distinct and overlapping functions of the HoxA and HoxD gene clusters in vertebrate limb development.
Overcoming Specificity Challenges in Hox Dominant-Negative Experiments: A Strategic Guide for Genetic Researchers
This article provides a comprehensive framework for researchers and drug development professionals tackling specificity issues in Hox dominant-negative experiments.
Precision Timing in Hox Gene Perturbation: Strategies for Optimizing Therapeutic Control in Development and Disease
This article provides a comprehensive framework for researchers, scientists, and drug development professionals seeking to optimize temporal control of Hox gene expression.
From Fin to Limb: A Comparative Analysis of Hox Gene Function in Mouse and Zebrafish Appendage Development
This article provides a comprehensive comparative analysis of Hox gene function in mouse limb and zebrafish fin development, tailored for researchers and drug development professionals.
Decoding the Hox Regulatory Network in Limb Development: From Genomic Profiling to Therapeutic Insights
This article provides a comprehensive resource for researchers and drug development professionals on the current methodologies, challenges, and applications of gene expression profiling for identifying Hox target genes in the...
Beyond Redundancy: Advanced Strategies for Unraveling Hox Gene Function in Development and Disease
Functional redundancy among Hox genes, resulting from gene duplication events in vertebrate evolution, has long been a significant obstacle in genetic studies, often masking phenotypic consequences in single-gene knockout models.
Overcoming Embryonic Lethality in Hox Research: New Models and Methods for Limb Development Studies
This article addresses the central challenge of embryonic lethality in Hox gene research, which has historically limited the study of their essential functions in vertebrate limb development.
Live Imaging of Hox Genes in Limb Buds: Unveiling Patterning, Dynamics, and Therapeutic Potential
This article synthesizes foundational knowledge and cutting-edge methodologies for visualizing Hox gene expression in developing limb buds using live-imaging technologies.
Mastering Limb Development: A Comprehensive Guide to Hox Gene Electroporation in Chick Embryos
This article provides a comprehensive resource for researchers utilizing electroporation to manipulate Hox gene expression in the chick limb bud, a cornerstone model in developmental biology and regenerative medicine.
Temporal Dynamics of HoxA and HoxD Gene Expression in Limb Development: Mechanisms, Regulation, and Clinical Implications
This article synthesizes current knowledge on the temporal dynamics of HoxA and HoxD gene expression during vertebrate limb development.